NLRP1 is activated by palmitic acid and induced in human metabolic dysfunction-associated steatohepatitis
Miriam Pinilla, Eulalia Campos Baños, María Antonia Martínez‐Sánchez, María Sánchez‐Villalobos, Alba Oliva‐Bolarín, Sara Rico‐Chazarra, Antonio J. Ruiz‐Alcaraz, Carlos Manuel Martínez, Adriana Mika, María Dolores Frutos, Bruno Ramos‐Molina, María Ángeles Núñez‐Sánchez, Ana B. Pérez‐Oliva
This study identifies increased NLRP1 expression in MASH liver samples and shows that palmitic acid activates the NLRP1 inflammasome in human cells.
bioRxiv · Nov 11, 2024 · PreprintMolecular Biology