Author

Zongchao Jia

Queen's UniversityORCID 0000-0002-9322-9394Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ethan BelroseiD· 1 shared Jianlin Wu· 1 shared Kody A. KluptiD· 1 shared Zhiyun YangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 1 mutual co-author link

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1 shared paperBiochemistry

Ethan BelroseORCID

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3 papers

Recent·Most cited

A structural screen for candidate polyphosphate binding surfaces in human membrane associated proteins

Jianlin Wu, Zongchao Jia

The paper develops a computational workflow to identify candidate polyphosphate binding surfaces in human membrane-associated proteins using structural and sequence-based approaches.

bioRxiv · Oct 26, 2026 · PreprintBiophysics

Polyphosphate as a Novel Regulator of Super-Enhancer Complexes: Disruption of Phase Separation and Gene Expression

Zhiyun Yang, Zongchao Jia

This paper shows polyP regulates gene expression by modifying super-enhancer complex components, disrupting phase separation and impairing transcription factor function.

Nucleic Acids Research · May 14, 2026Peer-reviewedMolecular Biology

Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K

Kody A. Klupt, Ethan Belrose, Zongchao Jia

The paper develops a de novo protein binder, CAM1, that inhibits eEF2K, an alpha kinase, with nanomolar affinity and comparable efficacy to a small molecule inhibitor.

bioRxiv · Dec 10, 2024 · PreprintBiochemistry