Kody A. Klupt

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

This paper introduces RFD2-MI, a deep learning framework for designing phosphotyrosine peptide binders, showing high specificity and affinity for phosphorylated targets.

The paper develops a de novo protein binder, CAM1, that inhibits eEF2K, an alpha kinase, with nanomolar affinity and comparable efficacy to a small molecule inhibitor.