Thomas J. Hardcastle

The paper maps meiotic DSBs in Arabidopsis using SPO11-1-oligonucleotides and shows their association with chromatin features and transposon activity.

The paper introduces a method to detect methylation loci and analyze differential methylation using statistical models and the segmentSeq and baySeq packages, showing improved power in simulations.

The paper introduces clusterSeq, a method for identifying co-expression clusters in high-throughput sequencing data by incorporating structural elements between experimental conditions.