Specialization of ubiquitin ligases to distinct nucleic acid sensors
Ibrahim Syed, Sheng Chen, David J. Peeler, Paul F. McKay, Marco Antonio Briones-Orta, Jennifer A. Bohn, Robin J. Shattock, Daniel Gonçalves-Carneiro
The paper identifies how SPRY domains in ubiquitin ligases recognize nucleic acid sensors, using AlphaFold to discover novel interactions and their implications for RNA vaccine design.
bioRxiv · Oct 1, 2025 · PreprintMolecular Biology