Robin J. Shattock

This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.

This paper develops a consensus HCV E1E2 antigen that engages germline B cell precursors of broadly neutralizing antibodies.

The paper identifies how SPRY domains in ubiquitin ligases recognize nucleic acid sensors, using AlphaFold to discover novel interactions and their implications for RNA vaccine design.

This paper develops a 3D printing method to create tunable drug delivery systems that control vaccine-induced antibody responses.

This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.

This study optimizes in vitro transcription (IVT) for long self-amplifying RNA (saRNA) using design of experiments, identifying key factors like magnesium and NTP interactions that maximize RNA yield.