David J. Peeler

This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.

This paper develops an injectable hydrogel platform with poly(orthoester) microparticles for long-term, zero-order drug release, demonstrating in vitro and in vivo efficacy for up to 12 months.

The paper identifies how SPRY domains in ubiquitin ligases recognize nucleic acid sensors, using AlphaFold to discover novel interactions and their implications for RNA vaccine design.

This paper develops a 3D printing method to create tunable drug delivery systems that control vaccine-induced antibody responses.

The paper introduces SPLiT-seq, a scalable scRNA-seq method, and applies it to analyze 109,069 cells from a mouse brain, identifying 13 main cell populations and developmental substructures.