Xusheng Zhang

Six3 and Six6 jointly regulate the identities and developmental trajectories of multipotent retinal progenitor cells in the mouse retina

This study uses single-cell RNA sequencing to analyze the role of Six3 and Six6 in retinal progenitor cell differentiation, identifying altered developmental trajectories and gene regulation in their dual deficiency.

Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

The paper reports the self-formation of human telencephalon-eye organoids with concentric tissue zones and directional RGC axon growth, identifying key molecular and cellular mechanisms.

Human retinal organoids release extracellular vesicles that regulate gene expression in target human retinal progenitors

This study identifies EVs from human retinal organoids and shows they regulate gene expression in retinal progenitors through miRNA cargo.