Wei Liu

This study uses single-cell RNA sequencing to analyze the role of Six3 and Six6 in retinal progenitor cell differentiation, identifying altered developmental trajectories and gene regulation in their dual deficiency.

The paper reports the self-formation of human telencephalon-eye organoids with concentric tissue zones and directional RGC axon growth, identifying key molecular and cellular mechanisms.

The paper introduces iEnhancer-CLA, a deep learning model for enhancer identification and strength prediction, showing improved accuracy and interpretability.

This study shows that CRISPR/Cas9 gene editing in adult mice prevents vision loss in a model of Fuchs' endothelial corneal dystrophy by disrupting the start codon of the mutant COL8A2 gene.

The paper identifies metabolic differences between mouse and human retinas, cones vs. rods, macula vs. periphery, and retina vs. RPE, highlighting distinct metabolic pathways and nutrient exchange.