Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
Srikanth Perike, Francisco J. González-González, Issam Abu-Taha, Frederick W. Damen, Ken Shibata Lizama, Anahita Aboonabi, Andrielle Elaine Capote, Yuriana Aguilar-Sánchez, Benjamin S. Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Joel W. Martin, Joseph G. Akar, Chad M. Warren, , Mark D. McCauley
This study shows PPP1R12C overexpression in AF patients and mice leads to MLC2a dephosphorylation, reduced atrial contractility, and increased AF inducibility.
bioRxiv · Apr 19, 2023 · PreprintMolecular Biology