Author

Issam Abu-Taha

West German Heart and Vascular Center EssenORCID 0000-0002-2298-8959Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

Dobromir DobreviD· 2 shared Anahita AboonabiiD· 1 shared Andrielle Elaine CapoteiD· 1 shared Anna NozzaiD· 1 shared Arvind SridhariD· 1 shared Beata Maria WolskaiD· 1 shared Benjamin S. LeviniD· 1 shared Chad M. WarreniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPathology

Dobromir DobrevORCID

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2 papers

Recent·Most cited

Time-dependent Mitochondrial Remodeling in Experimental Atrial Fibrillation and Potential Therapeutic Relevance

Xiaoyan Qi, Feng Xiong, Jiening Xiao, Kalai Mangai Muthukumarasamy, Yasemin Altuntaş, Yuan Zhong, Issam Abu-Taha, Florian Bruns, Marcel A. Tekook, Markus Kamler, Louis Robert Villeneuve, Anna Nozza, Martin G. Sirois, Jason M. Karch, Philippe Pasdois, , Stanley Nattel

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

bioRxiv · Jan 29, 2025 · PreprintPathology

Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation

Srikanth Perike, Francisco J. González-González, Issam Abu-Taha, Frederick W. Damen, Ken Shibata Lizama, Anahita Aboonabi, Andrielle Elaine Capote, Yuriana Aguilar-Sánchez, Benjamin S. Levin, Zhenbo Han, Arvind Sridhar, Jacob Grand, Joel W. Martin, Joseph G. Akar, Chad M. Warren, , Mark D. McCauley

This study shows PPP1R12C overexpression in AF patients and mice leads to MLC2a dephosphorylation, reduced atrial contractility, and increased AF inducibility.

bioRxiv · Apr 19, 2023 · PreprintMolecular Biology