Differential O-Glc elongation on the specific EGF repeat within a ligand binding domain regulates NOTCH1 signaling
Yohei Tsukamoto, Kazuhiro Aoki, Wataru Saiki, Natsumi Tsukamoto, Koki Kato, Yohei Hosokawa, Rie Sato, Yuki Fujita, Kana Fukazawa, Yuuki Kurebayashi, Yusuke Urata, Sae Uchiyama, Weiwei Wang, Akira Minami, Tadanobu Takahashi, , Hideyuki Takeuchi
The paper identifies a specific O-glucose glycan extension on NOTCH1 EGF10 that impacts ligand binding and signaling, revealing new enzymatic pathways and structural features of Notch glycosylation.
bioRxiv · Feb 20, 2025 · PreprintBiochemistry