Early endothelial activation at the blood-nerve barrier defines a hallmark of ALS
Ganesh Parameshwar Bhat, Santo Diprima, Cristian G. Beccaría, Paola Podini, Aurora Badaloni, Alessia Motta, Ilaria Brambilla, Luís F. Martins, Daniela Boselli, Stefano de Pretis, Giovanni Nardo, Caterina Bendotti, Nilo Riva, Matteo Iannacone, Angelo Quattrini, Dario Bonanomi
The paper identifies early endothelial activation at the blood-nerve barrier as a key feature of ALS, occurring before CNS vascular changes and motor neuron damage.
bioRxiv · Aug 31, 2025 · PreprintNeuroscience