Matteo Iannacone

CXCR3 on transferred T cells enables vaccine-boosted adoptive T-cell therapy in solid tumors

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

A lymphoid tissue chemokine checkpoint prevents loss of CD8+ T cell functionality

This study identifies a lymphoid tissue chemokine checkpoint that regulates CD8+ T cell release from dendritic cells, preventing loss of effector function.

Early endothelial activation at the blood-nerve barrier defines a hallmark of ALS

The paper identifies early endothelial activation at the blood-nerve barrier as a key feature of ALS, occurring before CNS vascular changes and motor neuron damage.

T cell-derived IFN-γ Suppresses T Follicular Helper Cell Differentiation and Antibody Responses

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.