Angelo Quattrini

This study shows that berberine improves motor deficits in SPG7 mutant mice by modulating mitochondrial permeability transition pore dynamics.

The paper identifies early endothelial activation at the blood-nerve barrier as a key feature of ALS, occurring before CNS vascular changes and motor neuron damage.

This study develops a glia-enriched 3D brain model from human iPSCs that mimics MS-related neurodegenerative phenotypes and intercellular communication.

The paper investigates how genetic variants in PNPLA3, MBOAT7, and TM6SF2 affect mitochondrial function in MASLD, showing that restoring these proteins improves mitochondrial bioenergetics and that circulating respirometry reflects hepatic mitochondrial status.

This study shows that L-PGDS in Schwann cells maintains myelin integrity by altering metabolism and producing ketone bodies and acetate.

This study shows that NEK1 haploinsufficiency in human iPSC-derived motoneurons and brain organoids impairs ciliogenesis, linking NEK1 mutations to ALS through reduced primary cilium formation.

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

This study identifies a non-neurogenic role of SVZ-eNPCs in regulating striatal GABAergic transmission and decision-making through IGFBPL-1 secretion.