Direct observation of secondary nucleation in huntingtin amyloid formation by High-Speed Atomic Force Microscopy
Chris van Ewijk, Greeshma Jain, Yari Katar Knelissen, Sourav Maity, Patrick C.A. van der Wel, Wouter H. Roos
This study uses high-speed atomic force microscopy to directly observe secondary nucleation in huntingtin amyloid formation, revealing dynamic processes and the role of flanking segments.
Journal of the American Chemical Society · Jun 12, 2025Peer-reviewedMolecular Biology