Author

Xingzhao Xiong

Tulane UniversityORCID 0000-0002-9384-4573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:differential expression· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Xiaowen LiuiD· 4 shared Liangliang SuniD· 2 shared Abdul Rehman BasharatiD· 1 shared Amanda B. HummoniD· 1 shared Binhai ZhuiD· 1 shared Emily R. SekeraiD· 1 shared Fei FangiD· 1 shared Fernando TobiasiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersBioinformatics

Xiaowen LiuORCID

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4 papers

Recent·Most cited

Enhancing Proteoform Sequence Coverage Using Top-Down Mass Spectrometry with In-Source Fragmentation and Middle-Down Mass Spectrometry

Xingzhao Xiong, Letu Qingge, Binhai Zhu, Xiaowen Liu

This study evaluates top-down and middle-down mass spectrometry approaches to enhance proteoform sequence coverage using in-source fragmentation and partial digestion, achieving over 90% coverage for three proteins.

Analytical Chemistry · Feb 2, 2026Peer-reviewedBioinformatics

Global Proteomic Analysis of Colorectal Cancers Stratified by Microsatellite Instability Subtype Reveals Protein Differences

Fernando Tobias, Emily R. Sekera, Xingzhao Xiong, Fei Fang, Heather Hampel, Rachel Pearlman, Xiaowen Liu, Liangliang Sun, Amanda B. Hummon

This study performs a global proteomic analysis of colorectal cancers stratified by microsatellite instability subtype, revealing protein differences associated with Lynch syndrome and other subtypes.

bioRxiv · Jan 29, 2026 · PreprintCancer Biology

Proteoform identification using multiplexed top-down mass spectra

Zhige Wang, Xingzhao Xiong, Xiaowen Liu

This paper introduces TopMPI, a tool for identifying proteoforms from multiplexed TD-MS/MS spectra, showing improved identification and reduced errors.

PROTEOMICS · Jul 30, 2025Peer-reviewedBioinformatics

TopDIA: A Software Tool for Top-Down Data-Independent Acquisition Proteomics

Abdul Rehman Basharat, Xingzhao Xiong, Tian Xu, Yong Zang, Liangliang Sun, Xiaowen Liu

TopDIA is a software tool for proteoform identification using TD-DIA-MS, showing improved identification compared to TD-DDA-MS in E. coli.

Journal of Proteome Research · Dec 6, 2024Peer-reviewedBioinformatics