SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the aging mouse testis
Anna Guitart-Solanes, Mayra Romero, Andrés Gámez-García, Irene Fernández-Duran, Bryan A. Niedenberger, Cristina Madrid-Sandín, Norah Spears, Ignasi Roig, Christopher B. Geyer, Alejandro Vaquero, Karen Schindler, Berta N. Vázquez
This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.
Nature Communications · Apr 28, 2026Peer-reviewedCell Biology