Anna Guitart-Solanes

This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

This study shows that p62 is involved in Lafora body formation and that its absence reduces glycogen aggregation in muscle and heart but worsens brain pathology in a mouse model of Lafora disease.