This study shows that SIRT7 maintains genome stability in aging mouse testes by regulating H3K36ac, preventing premature loss of spermatogonia and meiotic defects.

Nature Communications · Apr 28, 2026Peer-reviewedCell Biology

SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex

George Rasti, Maximilian Becker, Berta N. Vázquez, Maria Espinosa‐Alcantud, Irene Fernández-Duran, Andrés Gámez-García, Alessandro Ianni, Jéssica González, Laia Bosch‐Presegué, Anna Marazuela-Duque, Anna Guitart-Solanes, Sandra Segura‐Bayona, Joan Josep Bech‐Serra, Michael B. Scher, Lourdes Serrano, , Alejandro Vaquero

This study identifies SIRT1's role in regulating DNA damage signaling via interaction with the PP4 phosphatase complex, showing SIRT1 inhibits PP4 to modulate key DDR markers.

Nucleic Acids Research · Jun 13, 2023Peer-reviewedMolecular Biology

SirT7 auto-ADP-ribosylation regulates glucose starvation response through macroH2A1.1

Nicolás G. Simonet, Joshua K. Thackray, Berta N. Vázquez, Alessandro Ianni, Maria Espinosa‐Alcantud, Julia Morales‐Sanfrutos, Sarah Hurtado-Bagès, Eduard Sabidó, Marcus Buschbeck, Jay A. Tischfield, Carolina de la Torre, Manel Esteller, Thomas W Braun, Mireia Olivella, Lourdes Serrano, Alejandro Vaquero

This study identifies SirT7's dual role as a deacetylase and mADPRT enzyme, showing its regulation of glucose starvation response via interaction with macroH2A1.1.

bioRxiv · Aug 5, 2019 · PreprintMolecular Biology