Stuart J. Macdonald

This paper develops a likelihood-based method to estimate polyandry using pooled progeny sequencing and applies it to Drosophila melanogaster, finding 57% of families were sired by a single male.

The paper performs a GWAS on bristle number variation in Drosophila melanogaster, identifying significant genomic regions and candidate genes associated with abdominal and sternopleural bristle numbers.

This paper shows that low statistical power in pool-seq GWAS can create the illusion of polygenicity by masking simple genetic architectures through noise.

The paper uses extreme QTL mapping in Drosophila to identify genetic loci associated with zinc toxicity resistance, finding seven QTL and ten genes with genotype-by-treatment effects.

This study uses multi-timepoint RNA sequencing in Drosophila melanogaster to identify age-related gene expression changes, revealing non-linear patterns missed by two-timepoint comparisons.

The paper investigates tissue-specific gene expression responses to copper stress in Drosophila melanogaster using differential expression analysis and eQTL mapping across 96 inbred strains.

The paper uses ATAC-seq to analyze chromatin accessibility across four tissues in eight Drosophila melanogaster genotypes, identifying polymorphic regions and candidate causal variants after correcting for structural variants.

The paper identifies genetic variants that confer tolerance to transposition in Drosophila by linking them to double-strand break repair and germline differentiation.

The paper uses a bulked phenotyping approach to identify QTL associated with malathion resistance in Drosophila melanogaster, finding one QTL implicating Cyp6g1 and another distinct from previous GWAS results.

This paper introduces an X-QTL mapping strategy using bulked phenotyping and pooled sequencing in Drosophila, demonstrating its power and efficiency for identifying genetic loci associated with traits like caffeine resistance.

This study identifies genetic and regulatory factors influencing copper resistance in Drosophila using QTL mapping and RNA sequencing.

This study shows that the Drosophila transcription factor broad regulates leg disc morphogenesis by controlling ECM remodeling, cell shape changes, and metabolic activity during metamorphosis.

The paper identifies numerous structural variants in Drosophila genomes and shows they contribute to complex trait variation through allelic heterogeneity.

The paper uses two Drosophila mapping panels to identify genetic factors influencing starvation resistance, finding polygenic control and reproducible trait-associated sites across studies.

The paper identifies a 22-bp frameshift deletion in Ugt86Dd as a causative variant for nicotine resistance in Drosophila melanogaster through functional tests and genetic editing.