Yair J. Blumenfeld

The paper introduces SIMCO, a single-cell digital twin framework for evaluating PTL prevention drugs, identifying tetrahydrofolate, maprotiline, and aspirin-lansoprazole as top candidates.

This study demonstrates that in utero hematopoietic stem cell transplantation (HSCT) without conditioning can effectively engraft donor cells in FA mouse models, achieving high donor chimerism and potentially offering a safe prenatal treatment for FA.

This paper develops a noninvasive prenatal diagnosis method using ddPCR to detect single-gene disorders from maternal plasma, successfully identifying affected pregnancies as early as week 11.