Brice L Gaudilliere

A Transcriptomics-Based Computational Drug Repurposing Pipeline Identifies Simvastatin And Primaquine As Therapeutics For Endometriosis

This study identifies simvastatin and primaquine as potential therapeutics for endometriosis through computational drug repositioning, showing reduced pain and gene expression changes in animal models and lower disease risk in EMR data.

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

CDRPipe integrates single-cell and bulk transcriptomic perturbation data to improve drug repurposing predictions by combining complementary resources.

Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery

This study identifies persistent immune dysregulation in women with hypertensive disorders of pregnancy years after delivery, linked to increased cardiovascular disease risk.

Single-cell-level digital twins for preterm birth prevention strategies

The paper introduces SIMCO, a single-cell digital twin framework for evaluating PTL prevention drugs, identifying tetrahydrofolate, maprotiline, and aspirin-lansoprazole as top candidates.

Anticlustering for Sample Allocation To Minimize Batch Effects

The paper introduces anticlustering to balance batches and minimize batch effects in high-throughput sequencing, showing improved balance compared to existing methods.

Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

The effect of circulating neutralizing antibodies on the replication of SARS-CoV-2 variants following post-vaccination infections.

This study examines how pre-existing neutralizing antibodies affect viral shedding in post-vaccination SARS-CoV-2 infections, finding that higher titers reduce viral load and duration but are less effective against Omicron variants.

An immune signature of postoperative cognitive decline in elderly patients

This study identifies an immune signature predicting postoperative cognitive decline using single-cell and plasma proteomic data from elderly patients.

Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression

This study identifies hypothalamic circuitry involved in stress-induced insomnia and immunosuppression using genetic and optogenetic approaches.

Changes in pregnancy-related serum biomarkers early in gestation are associated with later development of preeclampsia

This study identifies changes in pregnancy-related serum biomarkers early in gestation as indicators of later preeclampsia development, validated in both human and mouse models.

Integration of Mechanistic Immunological Knowledge into a Machine Learning Pipeline Increases Predictive Power

The paper introduces a machine learning method that integrates immunological knowledge to improve predictive power from mass cytometry data.