The paper characterizes structural, biophysical, and virological properties of HIV-1 capsid-targeting antivirals, showing improved potency and stability through chemical modifications of PF74.

bioRxiv · Mar 25, 2026 · PreprintBiochemistry

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni, Jane Jardine, Roger-Junior Eloiflin, Adeline Augereau, Soumyabrata Guha, Moritz Schüssler, Pierre Le Hars, Joe McKellar, Tamara Carvalho, Jeanne Postal, Morgane Chemarin, Joanna Re, Florence Guivel‐Benhassine, , Nadine Laguette

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

The Journal of Experimental Medicine · Mar 24, 2026Peer-reviewedImmunology

Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with the nuclear speckle

Chiara Tomasini, Céline Cuche, Selen Ay, Maxence Collard, Bin Cui, Mohammad Rashid, Shaoni Bhattacharjee, Bruno Tello-Rubio, Julian Buchrieser, Charlotte Luchsinger, Cinzia Bertelli, Vladimir Nikolaevich Uversky, Felipe Diaz‐Griffero, Francesca Di Nunzio

This study investigates how HIV forms CPSF6 puncta and their fusion with nuclear speckles, identifying key domains and factors involved in this process and its role in viral persistence.

eLife · Jan 6, 2026Peer-reviewedMicrobiology

HIV-1 Infection Regulates Gene Expression by Altering Alternative Polyadenylation Through CPSF6 and CPSF5 Delocalization

Charlotte Luchsinger, Annie Zhi Dai, Hari Krishna Yalamanchili, Aiswarya Balakrishnan, Kai-Lieh Huang, Cinzia Bertelli, Bin Cui, Ramón Lorenzo-Redondo, Eric J. Wagner, Felipe Diaz‐Griffero

bioRxiv · Aug 7, 2025 · PreprintMicrobiology