Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite
Jessica Matos Kleiz-Ferreira, Marijke Brams, Peter J. Harrison, Casey I. Gallagher, Mieke Nys, Ysaline Donze, Andrew Quigley, Daniel Bertrand, Chris Ulens
This study determines the structure of a pH-sensitive ion channel from the scabies mite and shows how ivermectin modulates its activity through pH-dependent conformational changes.
Nature Communications · Mar 13, 2026Peer-reviewedBiochemistry