Author

Marijke Brams

KU LeuvenORCID 0000-0002-1830-7620Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Chris UlensiD· 3 shared Daniel BertrandiD· 2 shared Jessica Matos Kleiz-FerreiraiD· 2 shared Anant GharpureiD· 1 shared Andrew QuigleyiD· 1 shared Casey I. GallagheriD· 1 shared Cédric GovaertsiD· 1 shared Els PardoniD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

Chris UlensORCID

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3 papers

Recent·Most cited

Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite

Jessica Matos Kleiz-Ferreira, Marijke Brams, Peter J. Harrison, Casey I. Gallagher, Mieke Nys, Ysaline Donze, Andrew Quigley, Daniel Bertrand, Chris Ulens

This study determines the structure of a pH-sensitive ion channel from the scabies mite and shows how ivermectin modulates its activity through pH-dependent conformational changes.

Nature Communications · Mar 13, 2026Peer-reviewedBiochemistry

Structural basis for gating inhibition by the cytoplasmic domain in HCN1 channels

Valentina Zorzini, Jessica Matos Kleiz-Ferreira, Marijke Brams, Rodrigo U. Gallardo, Steven De Gieter, Jana Kusch, Chris Ulens

This study uses cryo-EM to analyze HCN1 channel variants, revealing structural differences in cAMP sensitivity and auto-inhibition mechanisms between HCN1 and HCN2 isoforms.

bioRxiv · Oct 14, 2025 · PreprintBiochemistry

A functionally conserved mechanism of modulation via a vestibule site in pentameric ligand-gated ion channels

Marijke Brams, Cédric Govaerts, Kumiko Kambara, Kerry L. Price, Radovan Spurný, Anant Gharpure, Els Pardon, Genevieve L. Evans, Daniel Bertrand, Sarah C. R. Lummis, Ryan E. Hibbs, Jan Steyaert, Chris Ulens

The paper identifies a conserved vestibule binding site in pLGICs and shows nanobodies can act as allosteric modulators, expanding drug design possibilities.

bioRxiv · Sep 17, 2019 · PreprintNeuroscience