Targeting the BAG-1 family of co-chaperones in lethal prostate cancer.
Antje Neeb, Ines Figueiredo, Denisa Bogdan, Laura Cato, Jutta Stober, Juan M. Jiménez‐Vacas, Victor Gourain, Irene I. Lee, Rebecca Seeger, Claudia Muhle‐Goll, Bora Gürel, Jonathan C. Welti, Daniel Nava Rodrigues, Jan Rekowski, Xintao Qiu, , Adam Sharp
This study investigates Thio-2's mechanism of action in inhibiting AR signaling in CRPC, showing it acts independently of BAG-1 isoforms and with potential AR NTD binding.
bioRxiv · Oct 17, 2022 · PreprintMolecular Biology