Author

Adam Sharp

Institute of Cancer ResearchORCID 0000-0002-3740-1612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Johann Sebastian De BonoiD· 3 shared Antje NeebiD· 2 shared Bora GüreliD· 2 shared Denisa BogdaniD· 2 shared Wei YuaniD· 2 shared Amanda SwainiD· 1 shared Ana FerreiraiD· 1 shared Andrew C.B. CatoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

Johann Sebastian De BonoORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 16, 2025

ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities

Nicole Pandell, Jacob Househam, Matteo Tartagni…·Marco Bezzi

ProMPt is a syngeneic mouse platform modeling prostate cancer heterogeneity, revealing MYC's role in progression and showing that MAPK inhibition plus translation blockade synergistically suppresses castration-resistant tumors.

1 citation

mousespatial transcriptomics

𝕏 PostBluesky

Cancer BiologyOncogenePeer-reviewedSep 12, 2024

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer

Sumaira Sardar, Christopher M. McNair, Lakshmi Ravindranath…·Ayesha A. Shafi

This study identifies CBP/p300 as critical for DNA repair in prostate cancer and shows that targeting it enhances therapeutic response.

21 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintOct 17, 2022

Targeting the BAG-1 family of co-chaperones in lethal prostate cancer.

Antje Neeb, Ines Figueiredo, Denisa Bogdan…·Adam Sharp

This study investigates Thio-2's mechanism of action in inhibiting AR signaling in CRPC, showing it acts independently of BAG-1 isoforms and with potential AR NTD binding.

DOI 10.1101/2022.10.17.512378

humanproteomics

𝕏 PostBluesky