Different alterations in mRNP composition trigger an increase in harmful R-loops
José Antonio Mérida-Cerro, Guillaume Chevreux, Benoı̂t Palancade, Ana G. Rondón, Andrés Aguilera
The paper identifies RNA-binding proteins and mRNP assembly perturbations that lead to R-loop accumulation and DNA damage, linking these processes to cancer and neurodegenerative diseases.
bioRxiv · Nov 11, 2024 · PreprintGenetics