Benoı̂t Palancade

DNA:RNA hybrid mutational landscapes reveal a common route to geneticinstability in evolving genomes

The paper identifies mutational signatures caused by DNA:RNA hybrids in yeast genomes, revealing a common mechanism of genetic instability through repair pathways.

Shining a light on the dark Nt-acetylome by integrating omics data

The paper integrates COFRADIC and sel-TRAP data to refine Nat substrate specificities and uncover cryptic Nt-acetylome substrates from alternative translation initiation.

A bifunctional snoRNA with separable activities in guiding rRNA 2'-O-methylation and scaffolding gametogenesis effectors

The paper identifies a bifunctional snoRNA, snR107, that guides rRNA modification and scaffolds gametogenesis effectors in fission yeast.

Different alterations in mRNP composition trigger an increase in harmful R-loops

The paper identifies RNA-binding proteins and mRNP assembly perturbations that lead to R-loop accumulation and DNA damage, linking these processes to cancer and neurodegenerative diseases.

Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import.

The paper identifies N-terminal signatures in yeast proteins that influence mitochondrial import, showing hydrophobic residues at position 2 are critical and conserved across Saccharomycotina yeasts.

Sen1 is a key regulator of transcription-driven conflicts

The paper shows Sen1 resolves transcription-driven conflicts and maintains genomic stability by terminating non-coding transcription and resolving R-loops.

A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription

The paper shows that the Nup84 complex restricts Ty retrotransposon transcription in yeast by tethering Ulp1 to NPCs, preventing retrotransposition.

The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain

This study shows Yra1 contributes to DNA double-strand break repair via homologous recombination, with its C-box domain being essential but sumoylation and ubiquitination dispensable.

A SUMO-dependent feedback loop senses and controls the biogenesis of nuclear pore subunits

The paper identifies a SUMO-dependent feedback loop that regulates NPC subunit biogenesis by sensing NPC integrity through Ulp1 and Hek2.