Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD
Kathryn M. Hoegeman, Jesse W. Wotring, Reid M. Fursmidt, Jedidiah Gaetz, Ehab M. Khalil, Douglas W. Selinger, Ilya Kovalenko, Tracey L. Schultz, Sean M. McCarty, Matthew J. O’Meara, Martin C. Clasby, Jonathan Z. Sexton
bioRxiv · Dec 25, 2025 · PreprintPharmacology & Toxicology