Jesse W. Wotring

Exposure to p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) Perturbs Cell State and Stem Cell Markers and Induces an Epidermal Phenotype in Human Breast Cells

This study shows that DDE exposure alters cell state and stem cell markers in breast cells, inducing an epidermal phenotype and upregulating keratinization pathways.

A High-Content Pseudotime Framework for Morphological Profiling of Dengue Virus Inhibitors from a Drug-Repurposing Library

This study identifies four DENV inhibitors from a drug library using high-content screening and a pseudotime model to map drug mechanisms onto viral life cycle stages.

High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

Identification and characterization of the functional LolB ortholog in Bacteroides

The paper identifies and characterizes a functional LolB ortholog in Bacteroides that rescues E. coli's lethal phenotype and shows its role in lipoprotein transport.

Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD