Phenotypic Screening Coupled with AI-Driven Target Deconvolution Identifies α-Terthienyl as a Dual DPP-IV/HSD17β13 Modulator with Efficacy in a Mouse Model of MASLD
Kathryn M. Hoegeman, Jesse W. Wotring, Reid M. Fursmidt…·Jonathan Z. Sexton
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Cambridge CollegeORCID 0000-0002-7103-6241Unclaimed ORCID profile · follow to get notified of new preprints
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Kathryn M. Hoegeman, Jesse W. Wotring, Reid M. Fursmidt…·Jonathan Z. Sexton
Srinivas Niranj Chandrasekaran, Eric Alix, John Arévalo…·Anne Elizabeth Carpenter
The paper presents a comprehensive genetic perturbation dataset using Cell Painting to analyze gene expression effects in human cells, revealing novel gene clusters and functional relationships.
Douglas W. Selinger, Timothy R. Wall, Eleni S. Stylianou…·Oren Levy
This paper introduces an AI-driven drug discovery framework that integrates knowledge graphs and large language models to automate and scale drug discovery processes.
Kara M. Foshay, Jae Hyun Lee, Li Zhang…·Bruce T. Lahn
The paper identifies gene occlusion erasure as a defining difference between naive and primed pluripotency states, showing Esrrb-dependent deocclusion sustains naive pluripotency.