Tomáš Mráček

Sequestration of the polyunsaturated fatty acids protects the cells with oxidative phosphorylation deficiency from ferroptosis

The paper identifies that OXPHOS-deficient cells sequester polyunsaturated fatty acids into triacylglycerols to protect against ferroptosis, observed in patient fibroblasts and hypoxia conditions.

Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease

The paper identifies recurrent mtDNA variants, particularly in the LSP2 promoter, as a cause of tubulointerstitial kidney disease in families with maternal inheritance.

COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly

The paper investigates the role of COX6B1 in cytochrome c oxidase assembly, finding it essential for both early redox-sensitive steps and late stabilization of the complex.