Cdt1 variants reveal unanticipated aspects of interactions with Cyclin/CDK and MCM important for normal genome replication.
Pedro N. Pozo, Jacob P. Matson, Yasemin Cole, Katarzyna M. Kedziora, Gavin D. Grant, Brenda R. S. Temple, Jeanette Gowen Cook
The paper investigates Cdt1 variants associated with Meier-Gorlin syndrome and a Drosophila allele to uncover their effects on MCM loading, Cyclin/CDK interactions, and genome replication.
Molecular Biology of the Cell · Oct 3, 2018Peer-reviewedMolecular Biology