Maternal IL-10 restricts fetal emergency myelopoiesis
Amélie Collins, James W. Swann, Melissa A. Proven, Chandani M. Patel, Carl A. Mitchell, Monica Kasbekar, Paul V. Dellorusso, Emmanuelle A. Passegue
The paper shows maternal IL-10 restricts fetal HSPCs from activating emergency myelopoiesis, leading to reduced myeloid cell production and neonatal neutropenia.
bioRxiv · Sep 13, 2023 · PreprintDevelopmental Biology