Emmanuelle A. Passegue

The paper develops NicheScribe, a method for consistently annotating stromal cells in the murine bone marrow niche using scRNA-seq data, enabling comparative analysis across different conditions.

The paper identifies shared and distinct molecular mechanisms of emergency myelopoiesis using scRNA-seq and develops tools to annotate and model hematopoietic differentiation.

This study identifies glutaminolysis as a therapeutic target to suppress emergency myelopoiesis by targeting glutaminase in hematopoietic stem and progenitor cells.

The paper identifies two bone marrow compartments and shows inflammation affects them differently, with type I interferon causing changes in mesenchymal stromal cells.

The paper shows maternal IL-10 restricts fetal HSPCs from activating emergency myelopoiesis, leading to reduced myeloid cell production and neonatal neutropenia.