THIK-1 channel mediates microglial glucose sensing and modulates AgRP neurons
Qingzhuo Liu, Jonathan Carter Bean, Jinjing Jian, Tong Zhou, Yuxue Yang, Meixin Sun, Yongxiang Li, Kristie Conde, Mengjie Wang, Yue Deng, Jiamin Qiu, Fuhui Wang, X. Liu, Yutian Liu, Jingjing Cheng, , Yong Xu
This study identifies THIK-1 channel as a glucose sensor in microglia that modulates AgRP neuron activity and feeding behavior in diet-induced obesity.
bioRxiv · Jan 16, 2026 · PreprintNeuroscience