Benjamin Russell Arenkiel

This study identifies a cerebellar-midbrain pathway that selectively gates social vocalizations and demonstrates that targeted neuromodulation can restore vocal behavior without improving motor coordination.

This study identifies a neural mechanism in mice where aberrant glutamatergic signaling from MBH SF1/ER neurons induces AN-like behaviors, suggesting BDNF as a therapeutic target.

The paper shows that G51D alpha-synuclein mice exhibit loss of primary cilia and neurotrophic signaling in specific brain regions, linking ciliary dysfunction to Parkinson's disease pathology.

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

The paper shows that Trpc5 in Esr1-expressing neurons of the MPOA controls paternal behavior in male mice by altering neuronal excitability and plasticity.

This study shows AgRP neurons are essential for maintaining body temperature during time-restricted feeding but not for body weight regulation when food is freely available.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study shows common AAV vectors transduce multiple human brain cell types in organotypic slices, with astrocytes showing the most protein expression, and introduces a pipeline for optimizing AAV vectors.

This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.

The paper investigates the activity patterns of PV and SST GABAergic neurons in the basal forebrain during odor-guided behavior in mice, finding distinct roles in reward and discrimination.

This study compares 11 AAV serotypes for transduction efficiency and specificity in murine olfactory sensory neurons using nasal inoculation.

The paper evaluates the transcriptional stability of cell types in ex vivo human brain tissue cultures over 14 days using single-nucleus RNA sequencing.

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

The paper introduces MAGIC, a cloning system enabling modular assembly of gene constructs for use in vertebrate models.

The paper shows that 5-HTDRN neurons are inhibited by GABA and dopamine, enabling meal initiation through their synergistic effects.

This study maps the expression and dosage of alpha-Synuclein across cell types in the mouse brain and periphery, identifying high and low expressing cell types and their potential role in Parkinson's disease.

The paper identifies a glutamatergic circuit from the basal forebrain to the ventral tegmental area that reduces appetite and causes anorexia-like behaviors by decreasing dopamine release in the nucleus accumbens.

This study compares odor responses in locust and mouse olfactory systems, finding conserved neural dynamics and computations that enhance odor contrast.

The paper shows neuronal activity induces Slc22a3 in astrocytes, which affects histone serotonylation and GABA release, leading to olfactory deficits.

The paper introduces a CRISPR toolkit for generating intersectional genetic mice to study cellular circuits, demonstrating its use in neuronal and ovarian populations.

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

The paper examines how cholinergic signaling in the basal forebrain changes during reward-seeking and learning behaviors, showing increased signaling during reward-seeking and suppression after reward delivery.

This study identifies ANKLE2 as a Zika virus target that regulates neuroblast asymmetric division, linking it to microcephaly and motor neuron disease through interactions with VRK1 and LLGL1.