Xing Fang

This study shows that inhibiting soluble epoxide hydrolase with TPPU improves cognitive function in diabetic-related dementia by enhancing cerebral blood flow and reducing neuroinflammation and gliosis.

The paper identifies a conserved postprandial metabolite, pTOS, that links nutrient intake to energy balance through a gut-brain pathway in pythons and mice, with potential relevance to humans.

This study shows that inhibiting soluble epoxide hydrolase (sEH) with TPPU improves cerebral blood flow autoregulation and cognition in Alzheimer's and diabetes-related dementia rat models.

The paper shows that 5-HTDRN neurons are inhibited by GABA and dopamine, enabling meal initiation through their synergistic effects.

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.

The paper longitudinally studies cerebral hemodynamics in TgF344-AD rats, finding impaired vascular responses and autoregulation before cognitive decline.