Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, David E. Leib, Vanessa Li, Rachel Harding, Stephanie Tran, Ran Chen, Hikari Tanaka, Amit Laxmikant Deshmukh, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, , Christopher E. Pearson
The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.
bioRxiv · Oct 24, 2022 · PreprintGenetics