Author

Terence Gall-Duncan

University of TorontoORCID 0000-0002-7314-7658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christopher E. PearsoniD· 3 shared Gagan B. PanigrahiiD· 2 shared Mahreen KhaniD· 2 shared Mustafa Hussain MehkaryiD· 2 shared Peixiang WangiD· 2 shared Tanya K. Prasolava· 2 shared Albert R. La SpadaiD· 1 shared Alexiane TouzéiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetics

Christopher E. PearsonORCID

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3 papers

Recent·Most cited

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntingtons disease

Pragya Goel, Praseuth Yang, Lisa A. Duvick, Orion Rainwater, Shannah Serres, Brennon L. O’Callaghan, Rocío Gómez‐Pastor, Mustafa Hussain Mehkary, Terence Gall-Duncan, Peter Langfelder, X. William Yang, Christopher E. Pearson, Patrick E. Rothwell, Harry T. Orr

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

bioRxiv · Dec 14, 2025 · PreprintNeuroscience

Interventionally targeting somatic CAG expansions can be a rapid disease-modifying therapeutic avenue: Preclinical evidence.

Terence Gall-Duncan, Sangyoon Y. Ko, Isabelle K. Quick, Mahreen Khan, Kristie Feng, Chase P. Kelley, Annabelle Coleman, Alexiane Touzé, Shuqian Tang, Mustafa Hussain Mehkary, Katsuyuki Yokoi, Casey R. Herrington, Justin You, Scott C. Lambie, Tanya K. Prasolava, , Christopher E. Pearson

This study shows that reducing somatic CAG expansions in HD mice improves motor function and disease markers, suggesting therapeutic potential for HD and similar repeat expansion diseases.

bioRxiv · Apr 25, 2025 · PreprintGenetics

Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, David E. Leib, Vanessa Li, Rachel Harding, Stephanie Tran, Ran Chen, Hikari Tanaka, Amit Laxmikant Deshmukh, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, , Christopher E. Pearson

The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.

bioRxiv · Oct 24, 2022 · PreprintGenetics