Dominique Lévesque

This study identifies ANP32A's role in DNA replication and repair by analyzing its proteomic interactions during replication stress and shows its involvement in end joining but not stalled-fork protection.

This study shows that NLRC5 expression in tumor cells enhances MHC-I and promotes antitumor immunity by activating immune cells and shaping the tumor microenvironment.

This study shows NLRC5 is essential for tumor immune surveillance and immunoediting, as its deficiency leads to increased tumor growth and reduced immune control.

The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.

The paper uses SILAC proteomics to show SOCS1 modulates 181 proteins in Hepa1-6 cells, with UBE2D being a key target involved in MET receptor regulation.