Hikari Tanaka

PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment

This study identifies PQBP1-dependent alternative RNA splicing as a mechanism underlying HFD-induced cognitive impairment through effects on synaptic vesicle release.

Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer's disease

This study identifies the Aβ-HMGB1 complex as a pathogenic factor in advanced Alzheimer's disease, showing it causes neuronal damage and that targeting HMGB1 improves symptoms in mouse models.

Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases

The paper investigates the roles of canonical and alternative RPA in CAG repeat diseases, finding that Alt-RPA antagonizes RPA's suppression of CAG expansions, contributing to disease pathogenesis.