Cancer BiologybioRxivPreprint
HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α
Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson…·Sita Kugel
This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.
DOI 10.64898/2026.10.02.754697