Author

Stephanie Dobersch

Fred Hutch Cancer CenterORCID 0000-0002-6633-4228Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Sita KugeliD· 3 shared Aditi MehtaiD· 1 shared Adrianne Wallace-PovirkiD· 1 shared Aidan SchutteriD· 1 shared Alexander E. Orellana· 1 shared Andreas GüntheriD· 1 shared Brian W. FreieiD· 1 shared Camilla Rydberg MillrudiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCancer Biology

Sita KugelORCID

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3 papers

Recent·Most cited

HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α

Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson, Jae Hyung Sim, Adrianne Wallace-Povirk, Nayvin W. Chew, Alexander E. Orellana, Joana E. Aggrey-Fynn, Liberalis Debraj Boila, Aidan Schutter, Ian M. Loveless, Gun Ho Jang, Shayan Avanessian, Gregory Lawrence Beatty, Suni R Hingorani, , Sita Kugel

This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.

bioRxiv · Oct 6, 2026 · PreprintCancer Biology

MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic ductal adenocarcinoma

Erin L. Ramsey, Stephanie Dobersch, Brian W. Freie, Nan Hyung Hong, Xiaoying Wu, Sita Kugel, Robert N. Eisenman, Patrick A. Carroll

This paper shows MondoA is essential for MYC-driven pancreatic cancer survival by coordinating MYC network activity with the integrated stress response, and small-molecule inhibition of MondoA kills cancer cells.

bioRxiv · Sep 3, 2025 · PreprintCancer Biology

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation

Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo‐Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach, Héctor A. Cabrera-Fuentes, Jürgen Bernhagen, Cho‐Ming Chao, Savério Bellusci, Andreas Günther, , Guillermo Barreto

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.

Nature Communications · Feb 16, 2021Peer-reviewedMolecular Biology