Mechanical Stiffening Promotes Growth, Invasion, and Mitogen-activated protein kinase kinase (MEK) Inhibitor Resistance in 3D Plexiform Neurofibroma Cultures
Kyungmin Ji, Chenjun Shi, Jitao Zhang
This study shows that stiff extracellular matrix promotes growth, invasion, and MEK inhibitor resistance in pNF1 tumors.
bioRxiv · Mar 9, 2026 · PreprintCancer Biology