Coupling of electron-bifurcation modules powers aromatic ring reduction beyond the biological redox window
Lena Appel, Anuj Kumar, Davide Tamborrini, Tomas C. Pascoa, Kanwal Kayastha, Ulrich Ermler, Tim Kettler, Stefan Bohn, Tristan Reif-Trauttmansdorff, Benjamin D. Engel, Jan M. Schuller, Matthias Boll
This study reveals how BCRII enzymes use electron-bifurcation modules to reduce aromatic rings beyond typical biological redox limits.
bioRxiv · Apr 13, 2026 · PreprintBiochemistry