Jan M. Schuller

Structural Basis of Redox-Coupled CO2 hydration by the Cyanobacterial NDH-1MS' complex

This paper determines the structure of the cyanobacterial NDH-1MS complex using cryo-EM, revealing a revised model for CO2 hydration coupled to proton transfer and electron flow.

Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase

The paper investigates the structure and dynamics of the archaeal ACDS complex, revealing a mechanism for efficient carbon transfer through transient interactions rather than stable complexes.

The anaerobic cryo-EM structure of the methanogenic Mtr complex reveals a nitrogenase-like cluster bound to its active site

The paper presents cryo-EM structures of the Mtr complex from Methanosarcina mazei, revealing a novel [Fe8S9C] cluster near the catalytic site and suggesting a link between methyl transfer and Na+ translocation.

Electron confurcation drives photosynthetic H2 production in cyanobacteria

This study identifies the electron partners of the HoxEFUYH hydrogenase in cyanobacteria, revealing its role in coupling reduced ferredoxin with NADH for H2 production.

The structure of a 2-MDa chloroplast RNA polymerase reveals unexpected evolutionary complexity

The paper reveals a 2-MDa chloroplast RNA polymerase structure in Chlamydomonas reinhardtii, showing unexpected complexity not linked to land plant evolution.

Structural Basis of Membrane Potential Coupled Vectorial CO2 Hydration by the DAB2 Complex in Chemolithoautotrophs

This paper presents the first cryo-EM structure of DAB2, revealing a PMF-driven CO2 hydration mechanism in chemolithoautotrophs.

Coupling of electron-bifurcation modules powers aromatic ring reduction beyond the biological redox window

This study reveals how BCRII enzymes use electron-bifurcation modules to reduce aromatic rings beyond typical biological redox limits.

Coordination of sequential RNase activities in an ancient molecular machine

The paper studies the evolution of the RNA exosome, showing how an ancient active RNase evolved into a regulatory hub coordinating sequential RNase activities.

Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage

This study presents the first molecular structure of methylthio-alkane reductase, revealing metalloclusters that inform its function and evolutionary relationship to nitrogenases.

Cryo-EM structure of Chlamydomonas Photosystem I complexedwith the alternative electron donor cytochrome c6

The paper presents a cryo-EM structure of a Cyt c:PSI complex from Chlamydomonas reinhardtii, revealing key interactions involved in electron transfer.

Structure of the energy converting methyltransferase (Mtr) of Methanosarcina mazei in complex with an oxygen-stress responsive small protein

The paper presents a cryo-EM structure of the Mtr complex from Methanosarcina mazei and identifies a small ORF protein, MtrI, involved in oxygen stress response.

H2 dependent modulation of Mtr activity by small protein MtrR in Methanosarcina mazei

The paper characterizes the small protein MtrR in Methanosarcina mazei, showing it modulates Mtr activity in response to hydrogen, affecting growth under varying H2 conditions.

Structural insights into late-stage photosystem II assembly by Psb32

This study determines the structure of two late-stage PSII assembly intermediates, revealing how Psb32 and Psb27 regulate OEC maturation and Mn4O5Ca cluster preparation.

2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

This study shows that 2-oxoglutarate induces dodecamer assembly of Methanosarcina mazei glutamine synthetase, enhancing its activity through a cooperative mechanism.

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

This study elucidates the molecular mechanism of redox-coupled sodium pumping in the Rnf complex using cryo-EM, biochemical assays, and simulations.

Frequent transitions in self-assembly across the evolution of a central metabolic enzyme

The paper investigates the evolutionary dynamics of self-assembly in prokaryotic citrate synthases, finding frequent transitions between different assembly types without strong functional consequences.