Author

Lena Appel

University of FreiburgORCID 0000-0003-2211-6445Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Matthias BolliD· 2 shared Anuj KumariD· 1 shared Benjamin D. EngeliD· 1 shared Davide TamborriniiD· 1 shared Dennis KosianiD· 1 shared Friedel DrepperiD· 1 shared Jan M. SchulleriD· 1 shared Kanwal KayasthaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Matthias BollORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 21, 2026

Powering methanogenesis from fatty acids by a twin-heme-mediated reverse redox-loop

Dennis Kosian, Lin Zhang, Lena Appel…·Matthias Boll

This paper reports cryo-EM structures of EMO and EMO-ETF complex from Syntrophus aciditrophicus, revealing a twin-heme-mediated reverse redox-loop mechanism for methanogenesis from fatty acids.

DOI 10.64898/2026.08.18.745454

bacteria (other)structural biology

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BiochemistrybioRxivPreprintApr 13, 2026

Coupling of electron-bifurcation modules powers aromatic ring reduction beyond the biological redox window

Lena Appel, Anuj Kumar, Davide Tamborrini…·Matthias Boll

This study reveals how BCRII enzymes use electron-bifurcation modules to reduce aromatic rings beyond typical biological redox limits.

1 citation

bacteria (other)structural biology

𝕏 PostBluesky